Professor Sian M Griffiths was President of the Faculty of Public Health of the Royal College of Physicians between 2001-4. In 2003 she chaired the Hong Kong SAR government's SARS Inquiry, joining the Chinese University of Hong Kong (CUHK) as Director of the School of Public Health and Primary Care in 2005. Since 2013 she is Emeritus Professor at CUHK and was Senior Adviser on International Academic Development to the previous Vice Chancellor until 2018. 

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In the UK, her current roles include Advisory Member of the Board of Public Health England and Chair of the PHE Global Health Committee, Non-Executive of Public Health Wales, Visiting Professor at Imperial College, London and Deputy Chair of the national charity Gambleaware. She was Chair of Staffordshire University’s Centre for Health and Development until July 2018. She has commented extensively in the media during the COVID-19 pandemic.