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Primary Care Clinical Trial Unit
As a leading hub for primary care research in the region, the JC School of Public Health and Primary Care is proud to establish the Primary Care Clinical Trial Unit (PCCTU) to:
- address pressing health challenges through high-quality, evidence-based clinical trials designed to improve patient outcomes and inform healthcare policies;
- advance knowledge and innovation in primary care through rigorous research, while fostering collaborations among healthcare professionals, researchers, and policymakers;
- drive evidence-based solutions to enhance the health and well-being of individuals and communities.
Our Mission
To deliver high-quality randomised controlled trials that advance and strengthen primary care.
Our Vision
To be an internationally recognised leader in primary care research, influencing policy, clinical practice, and population health.
Our Services
We provide end-to-end support for primary care clinical trials, from study concept and protocol development through trial set-up, delivery, and closure. Our services include trial design, regulatory and ethics submissions, site initiation, participant recruitment, data management, monitoring, analysis, and study close-out, ensuring the highest standards of scientific rigor, governance, and operational excellence.
Our Investigators
Focus Areas
- Mental Health:
- Developing and evaluating novel approaches for early detection, intervention, and management of mental health problems in primary care settings.
- Exploring the integration of mental health services into routine primary care to reduce stigma and improve access to care.
- Pain:
- Investigating innovative strategies for managing chronic pain, including musculoskeletal, neuropathic pain and chronic widespread pain, to enhance quality of life.
- Assessing the effectiveness of non-pharmacological interventions, such as digital health tools and exercise therapies, for pain management.
- Hypertension:
- Conducting trials to optimize hypertension management and prevention, with a focus on personalized care and lifestyle modifications.
- Evaluating the impact of mobile health technologies and patient-centered interventions on blood pressure control.
- Disease Prevention:
- Advancing primary prevention strategies, including lifestyle interventions and community-based programs, to reduce the burden of chronic diseases.
- Exploring innovative approaches to enhance vaccination uptake and health literacy in the population.
Trials
Trials in Active Recruitment
| 1 | Effects of mindfulness-based training on the microbiome of older adults with chronic stress: A randomised controlled trial Grant/Fund: GRF 14115025 PI: Prof. Samuel Wong |
| 2 | Risk Assessment and Management Program (RAMP)on knee osteoarthritis in primary Care – a one-year pragmatic randomized controlled trial Grant/Fund: HMRF 21220281 PI: Dr. Regina Sit |
| 3 | Life-Style Medicine for Chronic Musculoskeletal Pain in Older People: A pragmatic, randomized controlled clinical trial Grant/Fund: Private Funds PI: Dr. Regina Sit |
| 4 | Development of local adaptable acupuncture indications for patients with musculoskeletal and connective tissue diseases in Hong Kong primary care settings: Recommendations guided by the GRADE ADOLOPMENT approach Grant/Fund: Chinese Medicine Development Fund (CMDF) 23B2/021A PI: Dr. Regina Sit |
| 5 | Endothelins in mechanoaging and osteoarthritis: biomarker discovery and drug development Grant/Fund: The Collaborative Research Fund (CRF) PI: Dr. Regina Sit |
| 6 | The efficacy of an online exercise intervention for improving depressive symptoms among patients with subthreshold depression in primary care: a randomized controlled trial Grant/Fund: HMRF 21220291 PI: Prof. Samuel Wong |
| 7 | Can TElemedicine system replace doctor consultations to Achieve non-inferior blood pressure in patients with Controlled Hypertension (TEACH)? a randomised controlled trial and cost-minimization analysis Grant/Fund: HMRF 21220241 PI: Dr. Eric Lee |
| 8 | Effectiveness and mechanisms of isometric resistance exercise to reduce blood pressure in a Chinese population: a randomized-controlled trial Grant/Fund: GRF 14108224 PI: Dr. Eric Lee |
Recently Completed Trials
| 1 | Effects of mindfulness-based cognitive therapy for adults with post-traumatic stress disorder symptoms in primary care: a randomised controlled trial Grant/Fund: GRF #14609021 PI: Prof. Samuel Wong |
| 2 | The effects of mindfulness-based intervention for loneliness on older adults: a randomised controlled trial Grant/Fund: GRF #14609020 PI: Prof. Samuel Wong |
| 3 | Combining mind body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment: a randomized controlled trial Grant/Fund: HMRF #16170421 PI: Prof. Samuel Wong |
| 4 | The feasibility and effects of mindfulness-based relapse prevention (MBRP) on reducing craving and addictive behaviour in local adults with substance abuse disorders Grant/Fund: Beat Drug Fund #180056 PI: Prof. Samuel Wong |
| 5 | Dextrose Prolotherapy injection improves dynamic postural balance and reduces number of recurrent sprains in Chronic Ankle Instability: A one-year randomized placebo-controlled trial PI: Dr. Regina Sit |
| 6 | Feasibility and acceptability of mindfulness-based stress reduction program on patients with nocturnal hypertension: A pilot randomized controlled trial Grant/Fund: HMRF #20210541 PI: Dr. Eric Lee |
| 7 | Home blood pressure during night-time sleep as a better treatment target for patients with hypertension: a proof-of-concept randomized controlled trial Grant/Fund: HMRF #18190461 PI: Dr. Eric Lee |
Related Links
Our Trial Publications
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Join Us
The PCCTU is equipped with state-of-the-art infrastructure and staffed by a multidisciplinary team of experts in clinical trials, biostatistics, and primary care. We invite researchers, healthcare professionals, and community members to join us in our mission to promote evidence-based practices and improve the lives of patients through impactful research.
For more information about the PCCTU or to explore collaboration opportunities, please contact us at:
Tel: (852) 2609 5050
Email: pcctu.sphpc@cuhk.edu.hk
Address: Room 10, 4/F, Lek Yuen Health Centre, Sha Tin, New Territories, Hong Kong (Map)
