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Prof. Arwen Xiaoyun HUANG

黃曉韵教授

BMed (XJTU), BEng (XJTU), MMed (PKU), PhD (Heidelberg)

Research Assistant Professor

Email: arwen.x.huang@cuhk.edu.hk

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ORCID: 0000-0002-3389-9759

Scopus Author ID: 55569152300

ResearcherID:: MHR-1614-2025

Personal website: https://scholar.google.com/citations?hl=zh-TW&user=YywtKzkAAAAJ

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Academic Appointments

  • Professor (Adjunct), College of Life Science, Hunan Normal University

Biography

Prof. Huang, Xiaoyun (Arwen) is a Research Assistant Professor at the JC School of Public Health and Primary Care at the Chinese University of Hong Kong, with a distinctive interdisciplinary background that unites clinical medicine, computer science, and systems biology. Holding dual bachelor's degrees in Clinical Medicine and Computer Science, alongside a Master of Medicine in Oncology and a Ph.D. in Systems Biology, Dr. Huang works at the forefront of Intelligent Medicine—where advanced computational approaches meet real-world clinical challenges. This unique training empowers Arwen to view human health as a dynamic, interconnected system and to develop strategies that bridge molecular insights with patient outcomes.

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Driven by a vision to transform how we diagnose and treat complex diseases, Dr. Huang focuses on building next-generation models of human health through artificial intelligence-powered systems medicine. By integrating multi-omic, multi-modality, and multi-scale datasets, he is developing innovative frameworks that capture the full complexity of disease processes—from the molecular to the organismal level. Taking advantage of large-scale resources such as TCGA, GEO, HCA, and the UK Biobank, Dr. Huang aims to unlock new biological knowledge and translate it into precision diagnostics, targeted therapies, and predictive tools that can power a more proactive, personalized future of medicine.

Research Interests

  • Systems Medicine

  • Intelligent Medicine

  • Preventive Medicine

Selected Publications

  1. Yu, J., Jia, Y., Yu, Q., Lin, L., Li, C., Chen, B., Zhong, P., Lin, X., Li, H., Sun, Y., Zhong, X., He, Y., Huang, X., Lin, S. & Pan, Y. Deciphering complex antibiotic resistance patterns in Helicobacter pylori through whole genome sequencing and machine learning. Front Cell Infect Microbiol 13, 1306368, doi:10.3389/fcimb.2023.1306368 (2023).

  2. Li, J., Yang, Y., Wang, W., Xu, J., Sun, Y., Jiang, J., Tan, H., Ren, L., Wang, Y., Ren, Y., Zhang, Y., Xu, T., Jia, X., Huang, X. & Liu, P. Single-cell atlas of the immune microenvironment reveals macrophage reprogramming and the potential dual macrophage-targeted strategy in multiple myeloma. Br J Haematol 201, 917-934, doi:10.1111/bjh.18708 (2023).

  3. Zhu, Y., Chen, B., Yan, J., Zhao, W., Dou, P., Sun, N., Wang, Y. & Huang, X. BNIP3 Upregulation Characterizes Cancer Cell Subpopulation With Increased Fitness and Proliferation. Front Oncol 12, 923890, doi:10.3389/fonc.2022.923890 (2022).

  4. Wang, S., Jiang, M., Yang, Z., Huang, X. & Li, N. The role of distinct co-mutation patterns with TP53 mutation in immunotherapy for NSCLC. Genes Dis 9, 245-251, doi:10.1016/j.gendis.2020.04.001 (2022).

  5. Sun, Y. F., Wu, L., Liu, S. P., Jiang, M. M., Hu, B., Zhou, K. Q., Guo, W., Xu, Y., Zhong, Y., Zhou, X. R., Zhang, Z. F., Liu, G., Liu, S., Shi, Y. H., Ji, Y., Du, M., Li, N. N., Li, G. B., Zhao, Z. K., Huang, X. Y., Xu, L. Q., Yu, Q. C., Peng, D. H., Qiu, S. J., Sun, H. C., Dean, M., Wang, X. D., Chung, W. Y., Dennison, A. R., Zhou, J., Hou, Y., Fan, J. & Yang, X. R. Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma. Nat Commun 12, 4091, doi:10.1038/s41467-021-24386-0 (2021).

  6. Zhu, Y., Cang, S., Chen, B., Gu, Y., Jiang, M., Yan, J., Shao, F. & Huang, X. Patient Stratification of Clear Cell Renal Cell Carcinoma Using the Global Transcription Factor Activity Landscape Derived From RNA-Seq Data. Front Oncol 10, 526577, doi:10.3389/fonc.2020.526577 (2020).

  7. Robichon, K., Maiwald, T., Schilling, M., Schneider, A., Willemsen, J., Salopiata, F., Teusel, M., Kreutz, C., Ehlting, C., Huang, J., Chakraborty, S., Huang, X., Damm, G., Seehofer, D., Lang, P. A., Bode, J. G., Binder, M., Bartenschlager, R., Timmer, J. & Klingmuller, U. Identification of Interleukin1beta as an Amplifier of Interferon alpha-induced Antiviral Responses. PLoS Pathog 16, e1008461, doi:10.1371/journal.ppat.1008461 (2020).

  8. Natarajan, K. N., Miao, Z., Jiang, M., Huang, X., Zhou, H., Xie, J., Wang, C., Qin, S., Zhao, Z., Wu, L., Yang, N., Li, B., Hou, Y., Liu, S. & Teichmann, S. A. Comparative analysis of sequencing technologies for single-cell transcriptomics. Genome Biol 20, 70, doi:10.1186/s13059-019-1676-5 (2019).

  9. Huang, X., Liu, S., Wu, L., Jiang, M. & Hou, Y. High Throughput Single Cell RNA Sequencing, Bioinformatics Analysis and Applications. Adv Exp Med Biol 1068, 33-43, doi:10.1007/978-981-13-0502-3_4 (2018).

  10. Sobotta, S., Raue, A., Huang, X., Vanlier, J., Junger, A., Bohl, S., Albrecht, U., Hahnel, M. J., Wolf, S., Mueller, N. S., D'Alessandro, L. A., Mueller-Bohl, S., Boehm, M. E., Lucarelli, P., Bonefas, S., Damm, G., Seehofer, D., Lehmann, W. D., Rose-John, S., van der Hoeven, F., Gretz, N., Theis, F. J., Ehlting, C., Bode, J. G., Timmer, J., Schilling, M. & Klingmuller, U. Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib. Front Physiol 8, 775, doi:10.3389/fphys.2017.00775 (2017).

Last Updated: 5 March 2025

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